皮脂腺对外源性睾酮的差异反应。
Differential response of sebaceous glands to exogenous testosterone.
作者信息
Holland D B, Cunliffe W J, Norris J F
机构信息
Department of Dermatology, University of Leeds, General Infirmary, U.K.
出版信息
Br J Dermatol. 1998 Jul;139(1):102-3. doi: 10.1046/j.1365-2133.1998.02322.x.
To test the hypothesis that the seborrhoea of acne is an end-organ hyper-response to androgens, a standardized dose of 2% testosterone cream was applied to the forehead of eight prepubertal boys for 6 weeks and the effect determined by measurements of sebum excretion rate (SER). Three boys showed a 15-fold increase in SER and three boys were non-responders, whereas two boys had SER values between those of the responders and non-responders. These data show that sebaceous glands are stimulated by androgens to varying degrees and support the theory of an end-organ response in acne.
为了验证痤疮脂溢是皮脂腺对雄激素的终末器官过度反应这一假说，将标准化剂量的2%睾酮乳膏涂抹于8名青春期前男孩的前额，持续6周，并通过测量皮脂分泌率（SER）来确定其效果。3名男孩的SER增加了15倍，3名男孩无反应，而另外2名男孩的SER值介于有反应者和无反应者之间。这些数据表明，皮脂腺受雄激素刺激的程度各不相同，并支持痤疮终末器官反应的理论。
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