Colls B M, George P M
Christchurch Hospital, New Zealand.
Clin Oncol (R Coll Radiol). 1998;10(4):270-1. doi: 10.1016/s0936-6555(98)80019-8.
A patient who was given tamoxifen as adjuvant treatment for breast cancer developed very severe hypertriglyceridaemia, hypercholesterolaemia and acute pancreatitis after being treated for 4 months. The hyperlipidaemia was corrected after cessation of the tamoxifen and the institution of gemfibrozil treatment. This patient appears to have type IV hyperlipidaemia. It is suggested that, in such patients, tamoxifen should be used with extreme caution because the weakly oestrogenic effect of this agent can cause severe and life threatening hyperlipidaemia.
一名接受他莫昔芬辅助治疗乳腺癌的患者，在治疗4个月后出现了非常严重的高甘油三酯血症、高胆固醇血症和急性胰腺炎。停用他莫昔芬并开始使用吉非贝齐治疗后，高脂血症得到纠正。该患者似乎患有IV型高脂血症。建议在此类患者中，应极其谨慎地使用他莫昔芬，因为该药物的弱雌激素效应可能会导致严重且危及生命的高脂血症。
