Hance A J
Faculté de Médecine Xavier Bichat, Institut National de la Santé et de la Recherche Médicale, Paris, France.
Semin Respir Infect. 1998 Sep;13(3):197-205.
The pathogenesis of sarcoidosis has intrigued clinicians since the first descriptions of the disease, and a number of causes have been proposed. Among the candidate agents, the possible role of mycobacterial infection in the pathogenesis of sarcoidosis has attracted by far the most attention. The purpose of this review is to summarize current evidence concerning the role of mycobacterial infection in sarcoidosis. First, the similarities in clinical and histological features of tuberculosis and sarcoidosis that have raised suspicion that mycobacterial infection could be involved in the pathogenesis of sarcoidosis are discussed. In addition, experimental evidence for and against a role of mycobacterial infection is summarized, including recent attempts to detect mycobacterial DNA in clinical samples from patients with sarcoidosis by polymerase chain reaction.
自首次描述结节病以来，其发病机制一直吸引着临床医生，人们提出了多种病因。在众多候选因素中，分枝杆菌感染在结节病发病机制中的可能作用引起了迄今为止最多的关注。本综述的目的是总结关于分枝杆菌感染在结节病中作用的现有证据。首先，讨论了结核病和结节病在临床和组织学特征上的相似之处，这些相似之处引发了人们对分枝杆菌感染可能参与结节病发病机制的怀疑。此外，还总结了支持和反对分枝杆菌感染作用的实验证据，包括最近通过聚合酶链反应在结节病患者临床样本中检测分枝杆菌DNA的尝试。
