Dargent J L, Roufosse C, Delville J P, Kentos A, Delplace J, Kornreich A, Cochaux P, Hilbert P, Pradier O, Feremans W
Department of Pathology, CHU St Pierre/ULB-Institut Jules Bordet, Brussels, Belgium.
J Cutan Pathol. 1998 Aug;25(7):394-400. doi: 10.1111/j.1600-0560.1998.tb01764.x.
We report the case of a 20 year-old caucasian woman who presented a primary subcutaneous panniculitis-like T-cell lymphoma (SPTCL) as an invasive tumor of the chest wall. Herein, the neoplastic cells were found to express a CD3+CD8+ phenotype but also displayed variably the natural killer (NK)-associated antigens CD56 and CD57 as well as granzyme B. On cytological examination, these cells showed a large granular lymphocyte (LGL)-like morphology with presence of azurophilic granules in their cytoplasm. Electron dense and membrane bound granules like those found in cytotoxic T lymphocytes (CTL) were also demonstrated by electron microscopy. Neither rearrangement of the T-cell receptor subunits nor Epstein-Barr virus (EBV) genome was observed at the molecular level. The LGL-like features of the neoplastic cells found in this case and the presence of NK-associated antigens provide additional support to the cytotoxic derivation of most SPTCL.
我们报告了一例20岁的白种女性病例，该患者的原发性皮下脂膜炎样T细胞淋巴瘤（SPTCL）表现为胸壁的侵袭性肿瘤。在此病例中，肿瘤细胞被发现表达CD3 + CD8 +表型，但也可变地表达自然杀伤（NK）相关抗原CD56和CD57以及颗粒酶B。在细胞学检查中，这些细胞显示出大颗粒淋巴细胞（LGL）样形态，其细胞质中存在嗜天青颗粒。电子显微镜也证实了存在类似于细胞毒性T淋巴细胞（CTL）中的电子致密和膜结合颗粒。在分子水平上未观察到T细胞受体亚基的重排或爱泼斯坦-巴尔病毒（EBV）基因组。该病例中发现的肿瘤细胞的LGL样特征以及NK相关抗原的存在为大多数SPTCL的细胞毒性起源提供了额外的支持。
