人轮状病毒RV-3和S12/85在Caco-2细胞中的附着和生长依赖于VP4。
Attachment and growth of human rotaviruses RV-3 and S12/85 in Caco-2 cells depend on VP4.
作者信息
Kirkwood C D, Bishop R F, Coulson B S
机构信息
Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Parkville 3052, Victoria, Australia.
出版信息
J Virol. 1998 Nov;72(11):9348-52. doi: 10.1128/JVI.72.11.9348-9352.1998.
Abstract
Studies with human neonatal rotaviruses RV-3 and S12/85 and their reassortants showed that VP4 is a determinant of rotavirus attachment to and growth in Caco-2 cells. The binding of these viruses to MA104 and Caco-2 cells correlated with their growth ability. Virus sensitivity to trypsin and the VP4 fusion region may be implicated in these processes.
摘要
对人类新生儿轮状病毒RV - 3和S12/85及其重配体的研究表明，VP4是轮状病毒附着于Caco - 2细胞并在其中生长的决定因素。这些病毒与MA104和Caco - 2细胞的结合与其生长能力相关。病毒对胰蛋白酶的敏感性和VP4融合区域可能与这些过程有关。
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本文引用的文献
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