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Attachment and growth of human rotaviruses RV-3 and S12/85 in Caco-2 cells depend on VP4.人轮状病毒RV-3和S12/85在Caco-2细胞中的附着和生长依赖于VP4。
J Virol. 1998 Nov;72(11):9348-52. doi: 10.1128/JVI.72.11.9348-9352.1998.
2
Nucleotide sequence of the VP4-encoding gene of an unusual human rotavirus (HCR3).一种罕见人类轮状病毒（HCR3）的VP4编码基因的核苷酸序列。
Virology. 1993 Oct;196(2):825-30. doi: 10.1006/viro.1993.1540.
3
Inhibition of rotavirus infection in vitro and in vivo by a synthetic peptide from VP4.来自VP4的合成肽在体外和体内对轮状病毒感染的抑制作用。
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Both surface proteins (VP4 and VP7) of an asymptomatic neonatal rotavirus strain (I321) have high levels of sequence identity with the homologous proteins of a serotype 10 bovine rotavirus.一种无症状新生儿轮状病毒毒株（I321）的两种表面蛋白（VP4和VP7）与10型牛轮状病毒的同源蛋白具有高度的序列同一性。
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本文引用的文献

1
Solubilized and cleaved VP7, the outer glycoprotein of rotavirus, induces permeabilization of cell membrane vesicles.轮状病毒的外糖蛋白VP7经溶解和裂解后可诱导细胞膜囊泡的通透性增加。
J Gen Virol. 1997 Jun;78 ( Pt 6):1367-71. doi: 10.1099/0022-1317-78-6-1367.
2
Rotavirus contains integrin ligand sequences and a disintegrin-like domain that are implicated in virus entry into cells.轮状病毒含有整合素配体序列和一个类解整合素结构域，这些与病毒进入细胞的过程有关。
Proc Natl Acad Sci U S A. 1997 May 13;94(10):5389-94. doi: 10.1073/pnas.94.10.5389.
3
G3P2 rotaviruses causing diarrhoeal disease in neonates differ in VP4, VP7 and NSP4 sequence from G3P2 strains causing asymptomatic neonatal infection.导致新生儿腹泻病的G3P2轮状病毒在VP4、VP7和NSP4序列上与导致新生儿无症状感染的G3P2毒株不同。
Arch Virol. 1996;141(9):1661-76. doi: 10.1007/BF01718290.
4
Trypsin activation pathway of rotavirus infectivity.轮状病毒感染性的胰蛋白酶激活途径。
J Virol. 1996 Sep;70(9):5832-9. doi: 10.1128/JVI.70.9.5832-5839.1996.
5
Human rotavirus VP4 contains strain-specific, serotype-specific and cross-reactive neutralization sites.人轮状病毒VP4包含菌株特异性、血清型特异性和交叉反应性中和位点。
Arch Virol. 1996;141(3-4):587-600. doi: 10.1007/BF01718319.
6
Cleavage of rotavirus VP4 in vivo.轮状病毒VP4在体内的切割
J Gen Virol. 1996 Mar;77 ( Pt 3):391-5. doi: 10.1099/0022-1317-77-3-391.
7
Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein.由轮状病毒非结构糖蛋白引起的年龄依赖性腹泻。
Science. 1996 Apr 5;272(5258):101-4. doi: 10.1126/science.272.5258.101.
8
Genetic mapping indicates that VP4 is the rotavirus cell attachment protein in vitro and in vivo.基因图谱表明，VP4在体外和体内都是轮状病毒的细胞附着蛋白。
J Virol. 1996 Jan;70(1):487-93. doi: 10.1128/JVI.70.1.487-493.1996.
9
Variation in rotavirus virulence: a comparison of pathogenesis in calves between two rotaviruses of different virulence.轮状病毒毒力的差异：两种不同毒力的轮状病毒在犊牛发病机制中的比较。
Vet Pathol. 1993 May;30(3):223-33. doi: 10.1177/030098589303000302.
10
Murine rotavirus genes encoding outer capsid proteins VP4 and VP7 are not major determinants of host range restriction and virulence.编码鼠轮状病毒外衣壳蛋白VP4和VP7的基因不是宿主范围限制和毒力的主要决定因素。
J Virol. 1993 May;67(5):2448-55. doi: 10.1128/JVI.67.5.2448-2455.1993.

人轮状病毒RV-3和S12/85在Caco-2细胞中的附着和生长依赖于VP4。

Attachment and growth of human rotaviruses RV-3 and S12/85 in Caco-2 cells depend on VP4.

作者信息

Kirkwood C D, Bishop R F, Coulson B S

机构信息

Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Parkville 3052, Victoria, Australia.

出版信息

J Virol. 1998 Nov;72(11):9348-52. doi: 10.1128/JVI.72.11.9348-9352.1998.

DOI:10.1128/JVI.72.11.9348-9352.1998
PMID:9765487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC110359/
Abstract

Studies with human neonatal rotaviruses RV-3 and S12/85 and their reassortants showed that VP4 is a determinant of rotavirus attachment to and growth in Caco-2 cells. The binding of these viruses to MA104 and Caco-2 cells correlated with their growth ability. Virus sensitivity to trypsin and the VP4 fusion region may be implicated in these processes.

摘要

对人类新生儿轮状病毒RV - 3和S12/85及其重配体的研究表明，VP4是轮状病毒附着于Caco - 2细胞并在其中生长的决定因素。这些病毒与MA104和Caco - 2细胞的结合与其生长能力相关。病毒对胰蛋白酶的敏感性和VP4融合区域可能与这些过程有关。