Hyndman D J, Flynn T G
Department of Biochemistry, Queen's University, Kingston, Canada.
Biochim Biophys Acta. 1998 Aug 20;1399(2-3):198-202. doi: 10.1016/s0167-4781(98)00109-2.
We have isolated a human cDNA clone from small intestine that represents a new member of the aldo-keto reductase family. This new member showed 70% identity at the protein level to human aldose reductase and around 80% identity to other Chinese hamster and mouse reductases. The expression pattern shows that this message is located primarily in the adrenal gland, thus suggesting an involvement in steroid metabolism. It is also strongly expressed in the intestinal tract and has been called human small intestine reductase.
我们从小肠中分离出一个人类cDNA克隆，它代表醛糖-酮糖还原酶家族的一个新成员。这个新成员在蛋白质水平上与人类醛糖还原酶有70%的同源性，与其他中国仓鼠和小鼠的还原酶有大约80%的同源性。表达模式表明，这条信息主要位于肾上腺，因此提示其参与类固醇代谢。它在肠道中也有强烈表达，被称为人类小肠还原酶。
