1型人类免疫缺陷病毒（HIV-1）蛋白酶的克隆、分离、表达及诱变研究 - Suppr

Cloning, isolation, expression and mutagenesis studies on the human immuno-deficiency virus type 1 (HIV-1) protease.

作者信息

Garner J C, Shoolingin-Jordan P M

机构信息

Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, United Kingdom.

出版信息

Biochem Soc Trans. 1998 Aug;26(3):S287. doi: 10.1042/bst026s287.

DOI:10.1042/bst026s287

PMID:9766006

Abstract

摘要

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Cloning, isolation, expression and mutagenesis studies on the human immuno-deficiency virus type 1 (HIV-1) protease.1型人类免疫缺陷病毒（HIV-1）蛋白酶的克隆、分离、表达及诱变研究

Biochem Soc Trans. 1998 Aug;26(3):S287. doi: 10.1042/bst026s287.

Site-directed mutagenesis of HIV-1 protease: generation of mutant proteases with increased stability to autodigestion.人免疫缺陷病毒1型蛋白酶的定点诱变：生成对自身消化稳定性增强的突变蛋白酶

Adv Exp Med Biol. 1995;362:473-7. doi: 10.1007/978-1-4615-1871-6_62.

Analysis of resistance to human immunodeficiency virus type 1 protease inhibitors by using matched bacterial expression and proviral infection vectors.利用匹配的细菌表达载体和前病毒感染载体分析对1型人类免疫缺陷病毒蛋白酶抑制剂的耐药性。

J Virol. 1995 Sep;69(9):5431-6. doi: 10.1128/JVI.69.9.5431-5436.1995.

[HIV-1 proteinase mutant with an altered region of the active center].[具有活性中心区域改变的HIV-1蛋白酶突变体]

Mol Biol (Mosk). 1998 Jul-Aug;32(4):678-85.

Autoprocessing of the HIV-1 protease using purified wild-type and mutated fusion proteins expressed at high levels in Escherichia coli.利用在大肠杆菌中高水平表达的纯化野生型和突变融合蛋白对HIV-1蛋白酶进行自加工。

Eur J Biochem. 1991 Jul 15;199(2):361-9. doi: 10.1111/j.1432-1033.1991.tb16132.x.

Mutants of HIV-1 protease with enhanced stability to autodegradation.

Adv Exp Med Biol. 1995;362:387-98. doi: 10.1007/978-1-4615-1871-6_51.

Interaction of mutant forms of the HIV-1 protease with substrate and inhibitors.

Adv Exp Med Biol. 1991;306:483-7. doi: 10.1007/978-1-4684-6012-4_61.

Site-directed mutagenesis of a disulfide bridge in cathepsin D: expression, activation, purification, and characterization.组织蛋白酶D中二硫键的定点诱变：表达、激活、纯化及特性鉴定

Adv Exp Med Biol. 1995;362:285-7. doi: 10.1007/978-1-4615-1871-6_33.

In vitro processing of HIV-1 nucleocapsid protein by the viral proteinase: effects of amino acid substitutions at the scissile bond in the proximal zinc finger sequence.HIV-1核衣壳蛋白经病毒蛋白酶的体外加工：近端锌指序列中可裂解键处氨基酸取代的影响

Biochemistry. 2004 Apr 13;43(14):4304-12. doi: 10.1021/bi035625z.

Identification of amino acid residues of the retroviral aspartic proteinases important for substrate specificity and catalytic efficiency.

Adv Exp Med Biol. 1995;362:399-406. doi: 10.1007/978-1-4615-1871-6_52.

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Cloning, isolation, expression and mutagenesis studies on the human immuno-deficiency virus type 1 (HIV-1) protease.

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