El-Allawy R M, Sonne O, Gliemann J, Orskov H, Johansen K
Diabetologia. 1976 Oct;12(5):523-6. doi: 10.1007/BF01219518.
The concentration of biologically active insulin was measured by the isolated fat cell method in serum and urine from healthy subjects and compared with the concentration of immunoreactive insulin. In both urine and serum the values obtained by the two methods correlated closely; In addition, there was a close correlation between the concentration of biologically active and immunoreactive insulin in urine from maturity onset diabetics. Therefore, conclusions on the excretion in the urine and the urinary clearance of insulin, which are based on measurements of immunoreactive insulin, are also valid for biologically active insulin.
采用分离脂肪细胞法测定了健康受试者血清和尿液中生物活性胰岛素的浓度,并与免疫反应性胰岛素的浓度进行了比较。在尿液和血清中,两种方法测得的值密切相关;此外,成年型糖尿病患者尿液中生物活性胰岛素和免疫反应性胰岛素的浓度之间也密切相关。因此,基于免疫反应性胰岛素测量得出的关于胰岛素尿排泄和肾清除率的结论,对于生物活性胰岛素同样有效。