Taurog J D
Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center, Dallas 75235-8884, USA.
Am J Med Sci. 1998 Oct;316(4):250-6. doi: 10.1097/00000441-199810000-00005.
This review focuses on investigations of rats and mice transgenic for HLA-B27; these animals have been investigated for several years as potential models for the human spondyloarthropathies. Spontaneous multisystem disease occurs in rats with high expression of B27 and human beta2-microglobulin (hbeta2m). The disease is T-cell-dependent and is sensitive to both environmental and genetic manipulation. A spontaneous arthritis and enthesopathy has been observed by some investigators in nontransgenic mice which seems to be more prevalent in B27 transgenic mice. Peripheral arthritis has also been reported in B27 transgenic mice that lack mouse beta2m. Potential insights from these animals into the pathogenesis of B27-related disease are discussed.
本综述聚焦于HLA - B27转基因大鼠和小鼠的研究；这些动物作为人类脊柱关节病的潜在模型已被研究数年。B27和人β2微球蛋白（hβ2m）高表达的大鼠会发生自发性多系统疾病。该疾病依赖于T细胞，对环境和基因操作均敏感。一些研究者在非转基因小鼠中观察到了自发性关节炎和附着点病，这在B27转基因小鼠中似乎更为普遍。在缺乏小鼠β2m的B27转基因小鼠中也报道了外周关节炎。本文讨论了这些动物对B27相关疾病发病机制的潜在见解。
