[急性心肌梗死的实验性血管再生。III：游离核苷酸可溶性物质与某些脂肪族生物胺行为之间的相关性]
[Experimental revascularization of acute myocardial infarction. III: Correlation between the behaviour of the free nucleotide acid solubles and some aliphatic biogenic amines].
作者信息
Casti A, Rolli A, Guarnieri C, Barboso G, Reali N, Caldarera C M
出版信息
G Ital Cardiol. 1976;6(4):704-11.
Free nucleotide, polyamine and nucleic acid synthesis was studied in myocardial acute ischemia and reperfusion. An early stimulation of biosynthesis of these compounds was observed during ischemia, than later, a remarkable decrease of their specific radioactivity appeared. Reperfusion experiments cause a significant increase of nucleic acids and related compound biosynthesis. The results indicate that the biochemical mechanism of myocardial protein synthesis, under our experimental conditions are not irreversibly damaged by ischemia. In fact, the reperfusion causes a remarkable recovery of nucleic acid, free nucleotide and polyamine specific radioactivity. The changes during the period of infarction and subsequent reperfusion show that polyamines play a key role in myocardial ischemia and reperfusion.
研究了心肌急性缺血和再灌注过程中的游离核苷酸、多胺和核酸合成。在缺血期间观察到这些化合物生物合成的早期刺激，随后，它们的比放射性显著降低。再灌注实验导致核酸和相关化合物生物合成显著增加。结果表明，在我们的实验条件下，心肌蛋白质合成的生化机制并未因缺血而受到不可逆转的损害。事实上，再灌注导致核酸、游离核苷酸和多胺比放射性显著恢复。梗死期及随后再灌注期间的变化表明，多胺在心肌缺血和再灌注中起关键作用。
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