Adachi Y, Yamamoto T, Onishi S, Tanaka S, Wakisaka G
Gastroenterol Jpn. 1976;11(2):75-87. doi: 10.1007/BF02776703.
Two cases of Gilbert's syndrome and three cases of other diseases showed abnormally low plasma indocyanine green (ICG) clearance as contrated with normal or nearly normal plasma sulfobromphthalein (BSP) clearance. To evaluate the role of serum proteins in pathogenesis of these cases, ICG-binding patterns of serum proteins of the patients were compared with that of normal persons by the method of Sephadex G200 column chromatography. No qualitative differences in binding patterns were observed between serum proteins of the patients and normal persons. From these results, serum proteins were thought to be minor determinants of the hepatic ICG uptake mechanism. Because of normal or nearly normal plasma BSP clearance in these patients, the contents of hepatic organic anion-binding proteins, Y and Z, were thought to be sufficient. Possible qualitative abnormalities of the Y and/or Z proteins were also discussed.
两例吉尔伯特综合征患者和三例其他疾病患者的血浆吲哚菁绿（ICG）清除率异常降低，而血浆磺溴酞钠（BSP）清除率正常或接近正常。为评估血清蛋白在这些病例发病机制中的作用，采用葡聚糖凝胶G200柱层析法比较了患者与正常人血清蛋白的ICG结合模式。患者与正常人血清蛋白的结合模式未观察到定性差异。根据这些结果，血清蛋白被认为是肝脏ICG摄取机制的次要决定因素。由于这些患者的血浆BSP清除率正常或接近正常，因此认为肝脏有机阴离子结合蛋白Y和Z的含量是充足的。还讨论了Y蛋白和/或Z蛋白可能存在的定性异常。
