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1例中性粒细胞减少患者发生粘质口腔球菌严重感染:病例报告及文献复习

Severe infection caused by Stomatococcus mucilaginosus in a neutropenic patient: case report and review of the literature.

作者信息

Gruson D, Hilbert G, Pigneux A, Vargas F, Guisset O, Texier J, Boiron J M, Reiffers J, Gbikpi-Benissan G, Cardinaud J P

机构信息

Réanimation Médicale B, Hôpital Pellegrin, Bordeaux, France.

出版信息

Hematol Cell Ther. 1998 Aug;40(4):167-9.

PMID:9766921
Abstract

A 24-year-old female, in neutropenic phase after chemotherapy for acute myelogenous leukemia (on day 15) was admitted in intensive care unit for infectious pneumonia. Two strains of Stomatococcus mucilaginosus were isolated from peripheral blood cultures. No microorganisms were yielded from bronchoalveolar lavage. Patient's condition improved with prompt instigation of effective antibiotic therapy. This was the first case of septicemia and pneumonia, due to Stomatococcus mucilaginosus, in our unit. Only 26 cases occurring in neutropenic patients with underlying hematologic malignancies were reported in the literature and among these, only five cases with pneumonia were described. The complications of this normal inhabitant of the human oral cavity can be serious and fatal: septic shock, meningitis, acute respiratory distress syndrome. This study illustrate the possible virulence of Stomatococcus mucilaginosus in neutropenic patients.

摘要

一名24岁女性,在急性髓系白血病化疗后的中性粒细胞减少期(第15天)因感染性肺炎入住重症监护病房。从外周血培养物中分离出两株黏性口腔球菌。支气管肺泡灌洗未培养出微生物。患者在及时启动有效的抗生素治疗后病情好转。这是我们科室首例由黏性口腔球菌引起的败血症和肺炎病例。文献中仅报道了26例发生在患有血液系统恶性肿瘤的中性粒细胞减少患者中的病例,其中仅有5例描述了肺炎情况。这种人类口腔正常寄居菌的并发症可能很严重甚至致命:感染性休克、脑膜炎、急性呼吸窘迫综合征。本研究说明了黏性口腔球菌在中性粒细胞减少患者中可能具有的毒力。

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