Hiemisch H, Schütz G, Kaestner K H
Division Molecular Biology of the Cell I, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.
Gene. 1998 Oct 5;220(1-2):77-82. doi: 10.1016/s0378-1119(98)00409-0.
The 'winged helix' or 'forkhead' transcription factor gene family is defined by a common 100-amino-acid DNA-binding motif. Here, we describe the chromosomal position, start site of transcription, sequence and adult expression pattern of the mouse Fkh1/Mf1 (Forkhead homologue 1/mesoderm/mesenchyme forkhead 1) gene. This gene contains one exon and encodes a protein of 553 amino acids that is highly related to the mouse MFH1 protein. The Fkh1/Mf1 mRNA is expressed widely in adult tissues. Linkage analysis showed that the Fkh1/Mf1 gene is localized to chromosome 13 at 17.02cM from the centromer, in close proximity to Bmp6 and Hfh1, another distinct member of the winged helix gene family.
“翼状螺旋”或“叉头”转录因子基因家族由一个常见的100个氨基酸的DNA结合基序所定义。在此，我们描述了小鼠Fkh1/Mf1（叉头同源物1/中胚层/间充质叉头1）基因的染色体定位、转录起始位点、序列及成年期表达模式。该基因包含一个外显子，编码一个由553个氨基酸组成的蛋白质，该蛋白质与小鼠MFH1蛋白高度相关。Fkh1/Mf1 mRNA在成年组织中广泛表达。连锁分析表明，Fkh1/Mf1基因定位于13号染色体上，距着丝粒17.02cM处，紧邻Bmp6和Hfh1，后者是翼状螺旋基因家族的另一个独特成员。
