Sergiev P V, Lavrik I N, Dokudovskaya S S, Dontsova O A, Bogdanov A A
Belozersky Institute of Physico-Chemical Biology and School of Chemistry, Lomonosov Moscow State University, Moscow, 119899, Russia.
Biochemistry (Mosc). 1998 Aug;63(8):963-76.
The decoding center of the ribosome provides mRNA translation and the fidelity of the codon--anticodon interactions along with mRNA translocation in the course of protein biosynthesis. The three-dimensional structure of the ribosome decoding center is still unknown. However, up to now a number of direct and indirect experimental data on the structural and functional organization of the decoding center have been obtained. In this paper the main components of the decoding center are described on the basis of our own experimental results combined with data from the literature. A model of their spatial arrangement at the small ribosomal subunit is suggested.
核糖体的解码中心在蛋白质生物合成过程中提供mRNA翻译、密码子与反密码子相互作用的保真度以及mRNA易位。核糖体解码中心的三维结构仍然未知。然而，到目前为止，已经获得了一些关于解码中心结构和功能组织的直接和间接实验数据。本文结合文献数据，基于我们自己的实验结果描述了解码中心的主要组成部分。提出了它们在小核糖体亚基上的空间排列模型。
