Rossen K, Karabulut Thorup A, Hou-Jensen K, Krag Jacobsen G
Department of Pathology, Gentofte University Hospital, Hellerup, Denmark.
Br J Dermatol. 1998 Sep;139(3):472-4. doi: 10.1046/j.1365-2133.1998.02412.x.
BAX and related proteins encoded by the BCL2 gene family are involved in the regulation of apoptosis. BAX is an apoptosis-promoting protein. The slow growth of basal cell carcinoma (BCC) has so far been explained by a high apoptotic activity. We investigated immunohistochemically 27 BCCs for expression of the apoptosis-promoting BAX protein. BCC did not express detectable amounts of BAX immunohistochemically. The results indicate that apoptosis in BCC does not involve BAX protein. We propose that the apoptotic pathway in BCC is regulated by either less common members of the BCL2 gene family or bypasses the regulation of the BCL2 gene family.
BCL2基因家族编码的BAX及相关蛋白参与细胞凋亡的调控。BAX是一种促凋亡蛋白。迄今为止，基底细胞癌（BCC）生长缓慢一直被解释为具有较高的凋亡活性。我们采用免疫组织化学方法研究了27例基底细胞癌中促凋亡BAX蛋白的表达情况。基底细胞癌经免疫组织化学检测未表达可检测量的BAX。结果表明，基底细胞癌中的细胞凋亡不涉及BAX蛋白。我们认为，基底细胞癌中的凋亡途径要么由BCL2基因家族中较不常见的成员调控，要么绕过BCL2基因家族的调控。
