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氧气对大鼠脑和肝脏制剂中与5-羟色胺代谢相关的酶的影响。

The effect of oxygen on the enzymes concerned in the metabolism of 5-hydroxytryptamine by rat brain and liver preparations.

作者信息

Nelson D R, Huggins A K

出版信息

Gen Pharmacol. 1976 Sep;7(4):271-6. doi: 10.1016/0306-3623(76)90088-4.

DOI:10.1016/0306-3623(76)90088-4
PMID:976742
Abstract
  1. The effect of oxygen concentration at 1 atm on rat enzyme systems concerned in the synthesis and degradation of 5-hydroxytryptamine was studied in vitro. 2. Oxygen activated tryptophan hydroxylase and the deamination of both 5-hydroxytryptamine and tyramine by monoamine oxidase. 3. Oxygen did not affect the activities of 5-hydroxytryptophan decarboxylase or peroxidase.
摘要
  1. 在体外研究了1个大气压下氧气浓度对大鼠体内与5-羟色胺合成和降解相关的酶系统的影响。2. 氧气激活了色氨酸羟化酶以及单胺氧化酶对5-羟色胺和酪胺的脱氨基作用。3. 氧气不影响5-羟色氨酸脱羧酶或过氧化物酶的活性。

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