Woolverton W L, Trost R C
Pharmacol Biochem Behav. 1978 May;8(5):627-30. doi: 10.1016/0091-3057(78)90400-8.
Squirrel monkeys were trained in a choice procedure to discriminate a dose of 100 micrograms/kg cocaine from saline. Following an injection of cocaine, responding on the right lever was reinforced with food, whereas following an injection of saline, responding on the left lever was reinforced with food. A high degree of stimulus control (100% correct) was established within 20 experimental sessions. The dose-response function of cocaine on lever choice was then determined. When intermediate doses (10, 25 and 50 micrograms/kg) were administered prior to test sessions, a dose-dependent generalization decrement was seen. One monkey was found to discriminate as low as 25 microgram/kg cocaine from saline.
松鼠猴接受了一种选择程序的训练，以区分100微克/千克可卡因和生理盐水。注射可卡因后，按压右侧杠杆会得到食物强化，而注射生理盐水后，按压左侧杠杆会得到食物强化。在20次实验过程中建立了高度的刺激控制（100%正确）。然后确定了可卡因对杠杆选择的剂量反应函数。在测试前给予中等剂量（10、25和50微克/千克）时，出现了剂量依赖性泛化递减。发现一只猴子能够区分低至25微克/千克的可卡因和生理盐水。
