Kingsley D, Gad A, Catterall M
Gut. 1976 Aug;17(8):624-32. doi: 10.1136/gut.17.8.624.
During the past six years 40 patients have been treated with fast neutrons for inoperable adenocarcinoma of the stomach. A number of these patients have been studied in detail both radiologically and pathologically with regard to the effects of fast neutrons on both the tumour and normal stomach. After treatment there was a constant reduction in size of the stomach capacity when compared with a control group and the motility of the stomach was lost. Mucosal changes, which were noted radiologically, appeared to be dose related. Histologically most of the tumour was destroyed. Small clumps of cells were, however, found in all except one of the patients but only in areas of the stomach which had not received the standard dose. Marked fibrosis occurred and it is our impression that the amount of fibrosis is in excess of that seen with other forms of radiotherapy.
在过去六年中，40例无法手术的胃腺癌患者接受了快中子治疗。其中一些患者就快中子对肿瘤和正常胃部的影响进行了详细的放射学和病理学研究。与对照组相比，治疗后胃容量持续减小，且胃动力丧失。放射学观察到的黏膜变化似乎与剂量相关。组织学检查显示大部分肿瘤被破坏。然而，除1例患者外，所有患者均发现有小细胞团块，但仅存在于未接受标准剂量照射的胃部区域。出现了明显的纤维化，我们的印象是纤维化程度超过了其他形式放疗所见。
