Henderson R A, Talusan K, Hutton N, Yolken R H, Caballero B
Department of Pediatrics and Center for Human Nutrition, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Oct 1;19(2):150-7. doi: 10.1097/00042560-199810010-00008.
The purpose of this study was to determine whether alterations in body composition, resting energy expenditure (REE), and dietary energy intake are associated with growth retardation in HIV-positive children. Body composition (deuterium oxide dilution, skinfold measurements), REE (indirect calorimetry), and energy intake (24-hour weighed food intake) were evaluated in three groups: HIV-positive with growth retardation (HIV+Gr), HIV-positive with normal growth (HIV+); and HIV-uninfected with normal growth (HIV-). Children were between 2 and 11 years of age, afebrile, and free from acute infection. Forty-two children (13 HIV+Gr, 19 HIV+, 10 HIV-) were studied. Lean body mass was significantly reduced in HIV+Gr compared with HIV- (p < .05), and fat mass was significantly reduced in HIV+Gr and HIV+ compared with HIV- (p < .05). The percentages of lean and fat mass were not significantly different between groups, suggesting that differences in lean and fat mass were proportional to differences in body size. Consistent with reduced lean body mass, mean REE was significantly lower in HIV+Gr compared with HIV- (p < .05). Differences in mean REE/kg of body weight or lean body mass between groups were not statistically significant. A significant negative correlation was found between REE (kcal/kg/day) and weight-for-age (p = .04), and a trend with height-for-age Z-score (p = .07). Mean energy intake was not significantly different between groups. This study suggests that lean and fat mass are proportionately reduced in HIV-positive children with growth retardation. Further studies are necessary to delineate the relationship between energy balance and growth in children with HIV infection.
本研究的目的是确定身体成分、静息能量消耗（REE）和膳食能量摄入的改变是否与HIV阳性儿童的生长发育迟缓相关。对三组儿童进行了身体成分（氧化氘稀释法、皮褶测量）、REE（间接测热法）和能量摄入（24小时称重食物摄入量）的评估：生长发育迟缓的HIV阳性儿童（HIV+Gr）、生长正常的HIV阳性儿童（HIV+）；以及生长正常的未感染HIV儿童（HIV-）。儿童年龄在2至11岁之间，无发热，且无急性感染。共研究了42名儿童（13名HIV+Gr、19名HIV+、10名HIV-）。与HIV-组相比，HIV+Gr组的去脂体重显著降低（p<.05），与HIV-组相比，HIV+Gr组和HIV+组的脂肪量显著降低（p<.05）。各组间去脂体重和脂肪量的百分比无显著差异，表明去脂体重和脂肪量的差异与体型差异成比例。与去脂体重降低一致，HIV+Gr组的平均REE显著低于HIV-组（p<.05）。各组间平均REE/体重kg或去脂体重的差异无统计学意义。REE（千卡/千克/天）与年龄别体重之间存在显著负相关（p=.04），与年龄别身高Z评分呈趋势相关（p=.07）。各组间的平均能量摄入量无显著差异。本研究表明，生长发育迟缓的HIV阳性儿童的去脂体重和脂肪量成比例降低。有必要进一步研究以阐明HIV感染儿童能量平衡与生长之间的关系。
