Russell-Aulet M, Shapiro B, Jaffe C A, Gross M D, Barkan A L
Department of Internal Medicine, University of Michigan Health Systems and Department of Veterans Affairs, Ann Arbor 48109, USA.
J Clin Endocrinol Metab. 1998 Oct;83(10):3463-8. doi: 10.1210/jcem.83.10.5176.
GH plays a key role during adolescence in longitudinal bone growth and the attainment of peak bone mass. We explored the hypothesis that in early adulthood, bone mineral accretion and/or maintenance in men with normal GH and bone mineral status are related to the magnitude of endogenous GH secretion. Overnight plasma GH concentrations (sampled every 10 min from 2100-0500 h) were measured in 15 healthy, lean, Caucasian men (age, 24+/-1 yr; body mass index, 22.6+/-0.6 kg/m2; mean +/- SE). Total body, femur, and lumbar spine bone mineral mass/density were measured by dual energy x-ray absorptiometry. Total body and femoral bone mineral mass correlated with both total nocturnal GH and maximal GH concentrations even when bone mineral mass was adjusted by height (P = 0.005-0.02; r = 0.58-0.74). Neither spinal nor total body bone mineral density (BMD) correlated with GH. Maximum GH correlated with the BMD of all four femoral sites (P = 0.01-0.04; r = 0.55-0.66), whereas total nocturnal GH correlated with only one (trochanter; P = 0.01; r = 0.64) femoral site. Our data support the hypothesis that GH continues to play a role in the accretion and/or maintenance of bone mass in young men. This relationship is more evident in the bone mineral mass achieved than in the BMD.
生长激素（GH）在青春期纵向骨骼生长及达到峰值骨量过程中发挥关键作用。我们探究了这样一个假说：在成年早期，生长激素和骨矿物质状态正常的男性，其骨矿物质的增加和/或维持与内源性生长激素分泌量有关。对15名健康、体型偏瘦的白人男性（年龄24±1岁；体重指数22.6±0.6kg/m²；均值±标准误）测量了夜间血浆生长激素浓度（从21:00至05:00每10分钟采样一次）。通过双能X线吸收法测量全身、股骨和腰椎的骨矿物质质量/密度。即使骨矿物质质量经身高校正后，全身和股骨的骨矿物质质量仍与夜间总生长激素及最大生长激素浓度相关（P = 0.005 - 0.02；r = 0.58 - 0.74）。脊柱和全身的骨矿物质密度（BMD）均与生长激素无关。最大生长激素与所有四个股骨部位的骨矿物质密度相关（P = 0.01 - 0.04；r = 0.55 - 0.66），而夜间总生长激素仅与一个股骨部位（大转子；P = 0.01；r = 0.64）相关。我们的数据支持了这样的假说，即生长激素在年轻男性骨量的增加和/或维持中继续发挥作用。这种关系在获得的骨矿物质质量方面比在骨矿物质密度方面更为明显。
