A model to study cell injury: morphological changes of the proximal tubule of the rat kidney during ischemia and during recovery from ischemic injury in vivo.

Studies on structural cell changes as a function of ischemia time and studies on the recovery process of ischemically injured cells have implications for our general understanding of the features of cellular reaction to injury. For this reason a model was worked out to follow the morphological changes taking place in the proximal tubule of the rat kidney during ischemia and during recovery from an ischemic episode. The pars convoluta and the pars recta of the proximal tubule were examined separately and compared with one another.