通过端粒酶催化亚基mRNA对肝细胞癌进行基因诊断检测。

Genetic diagnostic test of hepatocellular carcinoma by telomerase catalytic subunit mRNA.

作者信息

Wada E, Hisatomi H, Moritoyo T, Kanamaru T, Hikiji K

机构信息

Center for Molecular Biology and Cytogenetics, SRL, Tokyo 191-0002, Japan.

出版信息

Oncol Rep. 1998 Nov-Dec;5(6):1407-12. doi: 10.3892/or.5.6.1407.

DOI:10.3892/or.5.6.1407

PMID:9769378

Abstract

This study investigated the relationship between telomerase activity and telomere length and between telomerase reverse transcriptase (hTERT) mRNA and telomere length. Both cancerous and non-cancerous tissues were studied in individuals with hepatic carcinoma. In this study, the telomere length in HCC livers had a wide range, no clear significant correlation was found between hTERT mRNA and telomere length. Telomerase activity was more strongly correlated with hTERT mRNA than with telomere length. The correlation between hTERT mRNA and telomerase activity shown here indicates that hTERT mRNA has potential for cancer diagnosis.

摘要

本研究调查了端粒酶活性与端粒长度之间以及端粒酶逆转录酶（hTERT）mRNA与端粒长度之间的关系。对肝癌患者的癌组织和非癌组织均进行了研究。在本研究中，肝癌肝脏中的端粒长度范围较广，未发现hTERT mRNA与端粒长度之间存在明显的显著相关性。端粒酶活性与hTERT mRNA的相关性比与端粒长度的相关性更强。此处所示的hTERT mRNA与端粒酶活性之间的相关性表明hTERT mRNA具有癌症诊断潜力。