[脑脊液中HIV-1 RNA定量对HIV脑炎诊断的临床重要性]

[Clinical importance of the quantification of HIV-1 RNA in cerebrospinal fluid for the diagnosis of HIV encephalitis].

作者信息

Bossi P, Dupré S, Dupin N, Coutellier A, Bricaire F, Lubetzki C, Katlama C, Calvez V

机构信息

Service de Virologie, Hôpital Pitié-Salpêtrière, Paris, France.

出版信息

Pathol Biol (Paris). 1998 Jun;46(6):423-5.

PMID:9769875

Abstract

We evaluated prospectively the HIV-1 RNA level in CSF as a marker of HIV encephalitis diagnosis. 110 HIV-1 infected patients (mean age: 39 years; sex-ratio M/F: 94/16) were tested for HIV-1 RNA in plasma and CSF. Lumbar punctures were performed to explore cognitive deficit, seizure or fever. HIV encephalitis was diagnosed in 15 patients (14%), other CNS disease in 34 (31%), and fever without CNS disease in 61 (55%). HIV-1 RNA was detectable in 93% of the plasma and in 62% of the CSF. No significant difference was observed in CSF HIV-1 RNA between patients with or without HIV encephalitis. CSF HIV-1 RNA was correlated with plasma HIV-1 RNA (p < 0.01), CSF protein (p < 0.01) and CSF white cell counts (p < 0.01). The absence of any significant difference between patients with or without HIV encephalitis, suggests that the CSF HIV-1 RNA level is not a good marker for its diagnosis.

摘要

我们前瞻性地评估了脑脊液中HIV-1 RNA水平作为HIV脑炎诊断标志物的情况。对110例HIV-1感染患者（平均年龄：39岁；男女比例为94/16）进行了血浆和脑脊液中的HIV-1 RNA检测。进行腰椎穿刺以探究认知缺陷、癫痫发作或发热情况。15例患者（14%）被诊断为HIV脑炎，34例（31%）患有其他中枢神经系统疾病，61例（55%）有发热但无中枢神经系统疾病。93%的血浆和62%的脑脊液中可检测到HIV-1 RNA。在患有或未患有HIV脑炎的患者之间，脑脊液HIV-1 RNA水平未观察到显著差异。脑脊液HIV-1 RNA与血浆HIV-1 RNA（p < 0.01）、脑脊液蛋白（p < 0.01）和脑脊液白细胞计数（p < 0.01）相关。患有或未患有HIV脑炎的患者之间不存在任何显著差异，这表明脑脊液HIV-1 RNA水平不是其诊断的良好标志物。