Prévost G, Colin D A, Staali L, Baba Moussa L, Gravet A, Werner S, Sanni A, Meunier O, Monteil H
Laboratoire de Toxinologie et d'Antibiologie Bactériennes (LTAB-UPRES-EA 1318), Université Louis Pasteur, Hôpitaux Universitaires de Strasbourg, France.
Pathol Biol (Paris). 1998 Jun;46(6):435-41.
The staphylococcal bi-component leukotoxins constitute a family included in the super-family of the beta-sheet-structured pore-forming toxins. They may be produced by Staphylococcus aureus and by Staphylococcus intermedius and their target cells vary according to the molecules. The mode of action proceeds by the sequential binding of the class S proteins, then by that of the class F proteins at the surface of the membranes. Then, the activation of cellular calcium-channels precedes the pore formation which seems to be sensitive to several monovalent cations. The cell response is inflammatory and includes the neosynthesis as well as the secretion of leukotriene B4, interleukin -8, histamine. The injection of leukotoxins to rabbits generates cell chemotaxis , vasodilatation, and tissue necrosis. The association of the production of leukotoxins with clinical syndromes concerns several aspects of the pathology of S. aureus, and confers to these leukotoxins an important role of virulence factors.
葡萄球菌双组分白细胞毒素属于β-折叠结构的成孔毒素超家族中的一个家族。它们可能由金黄色葡萄球菌和中间葡萄球菌产生，其靶细胞因分子而异。作用方式是S类蛋白先在膜表面顺序结合，然后是F类蛋白结合。接着，细胞钙通道的激活先于孔形成，孔形成似乎对几种单价阳离子敏感。细胞反应是炎症性的，包括白三烯B4、白细胞介素-8、组胺的新合成和分泌。给兔子注射白细胞毒素会产生细胞趋化、血管舒张和组织坏死。白细胞毒素的产生与临床综合征的关联涉及金黄色葡萄球菌病理学的几个方面，并赋予这些白细胞毒素毒力因子的重要作用。
