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[一种用于三种抗生素联合体外研究的三维模型。应用于哌拉西林、他唑巴坦和阿米卡星对五株肠杆菌的活性，作为其β-内酰胺耐药表型的函数]

[A three-dimensional model for in vitro study of the association of three antibiotics. Application to the activity of piperacillin, tazobactam and amikacin against five strains of enterobacteria as a function of their phenotype of beta-lactam resistance].

作者信息

Duez J M, Cordin X, Siebor E, Pechinot A, Chamard-Neuwirth C, Kazmierczak A

机构信息

Laboratoire de Bactériologie, CHU de Dijon, Hôpital du Bocage, Dijon, France.

出版信息

Pathol Biol (Paris). 1998 Jan;46(1):67-72.

PMID:9769939
Abstract

We described an in vitro 3-dimensional model to study the bactericidal activity of piperacillin (P), tazobactam (T) and amikacin (A) in combination against 5 strains of enterobacteria with different resistance patterns of beta-lactam antibiotics. A synergy was defined by calculation of sigma FBCP,T,A = BCp/MBCp + BCT/MBCT + BCA/MBCA and classic sigma FBCs for each double combination. The therapeutic value of each antibiotic was estimated by comparison of its bactericidal concentrations alone and in double or triple combination.

摘要

我们描述了一种体外三维模型，用于研究哌拉西林（P）、他唑巴坦（T）和阿米卡星（A）联合对5株具有不同β-内酰胺类抗生素耐药模式的肠杆菌的杀菌活性。通过计算σFBCP,T,A = BCp/MBCp + BCT/MBCT + BCA/MBCA以及每种双联组合的经典σFBCs来定义协同作用。通过比较每种抗生素单独以及双联或三联组合时的杀菌浓度来评估其治疗价值。

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