Courau E, Westeel V, Jacoulet P, Depierre A
Service de Pneumologie, CHU, Besançon.
Rev Pneumol Clin. 1998 May;54(2):65-70.
The Lambert-Eaton syndrome is an autoimmune disease affecting the presynapse of the neuromuscular junction. Proximal muscle fatigue of the limbs is improved by repeated maximal voluntary contractions. Generally, patients present hypo or areflexia and frequently a dry mouth syndrome. In 50% of the cases, the Lambert-Eaton syndrome is associated with small-cell bronchogenic carcinoma. The different treatments proposed in the literature for Lambert-Eaton paraneoplastic syndrome focus on treatment of the primary tumor. Symptomatic treatment of the junctional disorder are based on cholinergic drugs, immunosuppression and immunomodulation, useful in case of unsuccessful antineoplastic therapy.
兰伯特-伊顿综合征是一种影响神经肌肉接头突触前膜的自身免疫性疾病。通过反复进行最大自主收缩可改善肢体近端肌肉疲劳。一般来说，患者存在腱反射减退或消失，且常伴有口干综合征。在50%的病例中，兰伯特-伊顿综合征与小细胞支气管肺癌有关。文献中针对兰伯特-伊顿副肿瘤综合征提出的不同治疗方法主要集中在原发性肿瘤的治疗上。对于接头功能障碍的对症治疗基于胆碱能药物、免疫抑制和免疫调节，在抗肿瘤治疗失败的情况下可能有用。
