靶向癌症中的DNA甲基转移酶。

Targeting DNA methyltransferase in cancer.

作者信息

Szyf M

机构信息

Department of Pharmacology, McGill University, Montreal, PQ, Canada.

出版信息

Cancer Metastasis Rev. 1998 Jun;17(2):219-31. doi: 10.1023/a:1006023023787.

DOI:10.1023/a:1006023023787

PMID:9770119

Abstract

DNA methyltransferase is an enzyme responsible for generating and maintaining DNA methylation patterns. DNA methylation patterns control different genome functions, thus they are an important component of the epigenetic information. It has been recently postulated that DNA methyltransferase plays an important role in oncogenesis and that it is a candidate target for anticancer therapy. This commentary discusses the possible mechanisms through which DNA methyltransferase participates in oncogenesis and the rationale for targeting it in cancer.

摘要

DNA甲基转移酶是一种负责产生和维持DNA甲基化模式的酶。DNA甲基化模式控制着不同的基因组功能，因此它们是表观遗传信息的重要组成部分。最近有人提出，DNA甲基转移酶在肿瘤发生中起重要作用，并且它是抗癌治疗的候选靶点。本评论讨论了DNA甲基转移酶参与肿瘤发生的可能机制以及将其作为癌症治疗靶点的理论依据。