Perniciaro C, Rappaport K D, White J W
Department of Dermatology, Mayo Clinic Jacksonville, Florida 32224, USA.
Cutis. 1998 Sep;62(3):129-32.
A 45-year-old man with a glucagonoma and necrolytic migratory erythema is described. Clinical, radiographic, and histologic features were typical for this syndrome. However, a skin biopsy specimen for direct immunofluorescence examination revealed apoptotic keratinocytes that stained positive with immunoglobulins, fibrinogen, and C3. These immunofluorescence findings were initially interpreted erroneously as showing erythema multiforme or a related disorder. We present a unique case of necrolytic migratory erythema with positive direct immunofluorescence findings reflecting immunoglobulin and complement deposition within dyskeratotic epithelial cells.
本文描述了一名患有胰高血糖素瘤和坏死性游走性红斑的45岁男性。该综合征的临床、影像学和组织学特征均很典型。然而，用于直接免疫荧光检查的皮肤活检标本显示，凋亡的角质形成细胞对免疫球蛋白、纤维蛋白原和C3呈阳性染色。这些免疫荧光结果最初被错误地解释为多形红斑或相关疾病。我们报告了一例独特的坏死性游走性红斑病例，其直接免疫荧光结果呈阳性，反映了角化不良上皮细胞内免疫球蛋白和补体的沉积。
