Pao W, Duncan K O, Bolognia J L, Carroll C B, Hotez P J, Bessen D E
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Clin Infect Dis. 1998 Sep;27(3):430-3. doi: 10.1086/514685.
A previously healthy 13-month-old boy developed group A beta-hemolytic streptococcus bacteremia coinciding with numerous eruptive subcutaneous lesions primarily on his extremities. Skin biopsy revealed infectious panniculitis; gram-positive cocci were present within both fat lobules and septa. Molecular genetic analysis of an isolate from the patient's blood revealed an emm type 4 organism displaying the emm chromosomal pattern E that is characteristic of opacity factor-producing strains; the organism also harbored the gene encoding for streptococcal pyrogenic exotoxin C (speC). To our knowledge, this clinical presentation has not yet been described in the spectrum of infections directly caused by group A beta-hemolytic streptococci.
一名此前健康的13个月大男孩发生了A组β溶血性链球菌菌血症，同时在其四肢出现了大量皮下疹性病变。皮肤活检显示为感染性脂膜炎；脂肪小叶和间隔内均存在革兰氏阳性球菌。对患者血液分离株进行的分子遗传学分析显示，该菌株为emm 4型，呈现出emm染色体模式E，这是产生不透明因子菌株的特征；该菌株还携带编码链球菌致热外毒素C（speC）的基因。据我们所知，这种临床表现尚未在A组β溶血性链球菌直接引起的感染范围内被描述过。
