Guerra C E, Betts R F, O'Keefe R J, Shilling J W
Department of Medicine, Infectious Diseases, University of Rochester School of Medicine and Dentistry, New York 14642, USA.
Clin Infect Dis. 1998 Sep;27(3):639-40. doi: 10.1086/514714.
Bacille Calmette-Guérin (BCG), an attenuated strain of Mycobacterium bovis, is one of the most effective agents in the treatment of superficial bladder cancer. BCG osteomyelitis is an infrequent complication of intravesicular BCG therapy; only five cases of BCG vertebral osteomyelitis have been reported in the literature. Similarly, the infection of an indwelling extravascular device by BCG is rare; there is only one previous report documenting infection associated with an automated implantable cardiac defibrillator. We report a case of BCG osteomyelitis involving a hip arthroplasty that occurred after intravesicular administration of BCG for bladder cancer, and we review the risk factors predisposing to such infections and their treatment.
卡介苗（BCG）是牛分枝杆菌的减毒株，是治疗浅表性膀胱癌最有效的药物之一。卡介苗骨髓炎是膀胱内卡介苗治疗罕见的并发症；文献中仅报道了5例卡介苗性脊椎骨髓炎。同样，卡介苗感染植入的血管外装置也很罕见；之前仅有一份报告记录了与自动植入式心脏除颤器相关的感染。我们报告一例膀胱癌膀胱内注射卡介苗后发生的累及髋关节置换术的卡介苗骨髓炎病例，并回顾了易发生此类感染的危险因素及其治疗方法。
