Lee Susan C, Geannette Christian S
Hospital for Special Surgery, Department of Radiology and Imaging, United States of America.
Hospital for Special Surgery, Department of Radiology and Imaging, United States of America.
Clin Imaging. 2020 Dec;68:179-183. doi: 10.1016/j.clinimag.2020.07.016. Epub 2020 Jul 25.
Mycobacterium bovis (M. bovis) Bacillus Calmette-Guerin (BCG) - an attenuated strain of M. bovis - is closely related to Mycobacterium tuberculosis and may be used as a vaccine against tuberculosis as well as a treatment for urinary bladder cancer. Complications of M. bovis BCG administration, while rare, can occur. While a few cases of vertebral osteomyelitis secondary to BCG therapy exist in the literature, and while there are case reports of osteomyelitis and septic arthritis from BCG vaccination (Chen et al., 2017; Huang et al., 2019; Lin et al., 2015 [1-3]), there are no reported cases of osteomyelitis and septic arthritis involving the foot from BCG therapy for urinary bladder cancer. We present an unusual presentation of osteomyelitis and septic arthritis of the tarsometatarsal joints after M. bovis BCG therapy for urinary bladder cancer. We will describe MRI and ultrasound findings in our case of M. bovis BCG osteomyelitis and septic arthritis.
牛分枝杆菌（M. bovis）卡介苗（BCG）——一种减毒的牛分枝杆菌菌株——与结核分枝杆菌密切相关，可作为结核病疫苗以及膀胱癌的治疗药物。牛分枝杆菌卡介苗给药的并发症虽然罕见，但仍可能发生。虽然文献中有几例继发于卡介苗治疗的椎体骨髓炎病例，也有卡介苗接种导致骨髓炎和脓毒性关节炎的病例报告（Chen等人，2017年；Huang等人，2019年；Lin等人，2015年[1 - 3]），但尚无膀胱癌卡介苗治疗导致足部骨髓炎和脓毒性关节炎的报告病例。我们报告了一例膀胱癌卡介苗治疗后跗跖关节骨髓炎和脓毒性关节炎的不寻常表现。我们将描述我们病例中牛分枝杆菌卡介苗骨髓炎和脓毒性关节炎的MRI和超声检查结果。
