Lee K H, Marden J J, Thompson M S, MacLennan H, Kishimoto Y, Pratt S J, Schulte-Merker S, Hammerschmidt M, Johnson S L, Postlethwaite J H, Beier D C, Zon L I
Department of Cardiology, Children's Hospital, Boston, Massachusetts, USA.
Dev Genet. 1998;23(2):97-103. doi: 10.1002/(SICI)1520-6408(1998)23:2<97::AID-DVG1>3.0.CO;2-0.
The BMP family of polypeptide growth factors has been shown to play diverse roles in establishing embryonic patterning and tissue fates. We report the cloning of the zebrafish homologue of BMP-2, examine its expression during embryogenesis, and find that it is localized to the distal end of the long arm of zebrafish chromosome 20. A missense mutation of the bmp2 gene has recently been shown to be responsible for the early dorsalized phenotype of the zebrafish swirl mutant [Kishimoto et al., 1997]. Given the dynamic expression of bmp2 in the developing embryo and the complex interactions of BMP signaling response in vertebrates, it is possible that other mutant phenotypes, due to altered bmp2 gene expression, will eventually map to or interact with this genetic locus.
多肽生长因子的骨形态发生蛋白（BMP）家族已被证明在建立胚胎模式和组织命运方面发挥着多种作用。我们报告了斑马鱼BMP - 2同源物的克隆，研究了其在胚胎发育过程中的表达，并发现它定位于斑马鱼20号染色体长臂的远端。最近发现bmp2基因的一个错义突变是斑马鱼漩涡突变体早期背化表型的原因[岸本等人，1997年]。鉴于bmp2在发育中的胚胎中的动态表达以及脊椎动物中BMP信号反应的复杂相互作用，由于bmp2基因表达改变而导致的其他突变表型最终有可能定位于此遗传位点或与其相互作用。
