Balkovetz D F, Lipschutz J H
Department of Medicine, University of Alabama at Birmingham, USA.
Int Rev Cytol. 1999;186:225-60. doi: 10.1016/s0074-7696(08)61055-4.
Mesenchymal-epithelial interactions are important for many biological processes in epithelial organs such as the kidney. Hepatocyte growth factor (HGF) is a mesenchymally derived polypeptide cytokine that acts through its tyrosine kinase c-met receptor and is an important mediator of these interactions. This article reviews data showing the in vitro actions of HGF on renal epithelial cells that result in such diverse responses as mitogenesis, motogenesis, and morphogenesis. It also examines the in vivo evidence linking HGF and the c-met receptor to kidney development, regeneration following injury, and renal disease. Elucidating cellular mechanisms underlying the coordinated control of diverse HGF-induced phenotypic changes in renal epithelia in vitro should contribute to a clearer understanding of complex biological processes such as organogenesis, regeneration, and carcinogenesis in epithelial organs such as the kidney.
间充质-上皮相互作用对肾脏等上皮器官的许多生物学过程至关重要。肝细胞生长因子（HGF）是一种间充质来源的多肽细胞因子，通过其酪氨酸激酶c-met受体发挥作用，是这些相互作用的重要介质。本文综述了有关HGF对肾上皮细胞的体外作用的数据，这些作用导致了诸如有丝分裂、运动发生和形态发生等多种反应。它还研究了将HGF和c-met受体与肾脏发育、损伤后再生及肾脏疾病联系起来的体内证据。阐明体外HGF诱导肾上皮细胞多种表型变化的协调控制背后的细胞机制，应有助于更清楚地理解诸如肾脏等上皮器官中的器官发生、再生和致癌作用等复杂生物学过程。
