β-淀粉样前体蛋白分泌形式在正常和失忆小鼠中的记忆增强作用。
Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.
作者信息
Meziane H, Dodart J C, Mathis C, Little S, Clemens J, Paul S M, Ungerer A
机构信息
Laboratoire Ethologie et Neurobiologie, Université Louis Pasteur, Unité de Recherche Associée-Centre National de la Recherche Scientifique 1295, 7 rue de l'Université, 67000 Strasbourg, France.
出版信息
Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12683-8. doi: 10.1073/pnas.95.21.12683.
Abstract
When administered intracerebroventricularly to mice performing various learning tasks involving either short-term or long-term memory, secreted forms of the beta-amyloid precursor protein (APPs751 and APPs695) have potent memory-enhancing effects and block learning deficits induced by scopolamine. The memory-enhancing effects of APPs were observed over a wide range of extremely low doses (0.05-5,000 pg intracerebroventricularly), blocked by anti-APPs antisera, and observed when APPs was administered either after the first training session in a visual discrimination or a lever-press learning task or before the acquisition trial in an object recognition task. APPs had no effect on motor performance or exploratory activity. APPs695 and APPs751 were equally effective in the object recognition task, suggesting that the memory-enhancing effect of APPs does not require the Kunitz protease inhibitor domain. These data suggest an important role for APPss on memory processes.
摘要
当向执行涉及短期或长期记忆的各种学习任务的小鼠脑室内注射时，β-淀粉样前体蛋白的分泌形式（APPs751和APPs695）具有强大的记忆增强作用，并能阻断东莨菪碱诱导的学习缺陷。APPs的记忆增强作用在极宽的极低剂量范围内（脑室内注射0.05 - 5000皮克）都能观察到，可被抗APPs抗血清阻断，并且在视觉辨别或杠杆按压学习任务的第一次训练后或物体识别任务的习得试验前注射APPs时也能观察到。APPs对运动性能或探索活动没有影响。APPs695和APPs751在物体识别任务中同样有效，这表明APPs的记忆增强作用不需要Kunitz蛋白酶抑制剂结构域。这些数据表明APPss在记忆过程中起重要作用。
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