Steckler T, Drinkenburg W H, Sahgal A, Aggleton J P
Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany.
Prog Neurobiol. 1998 Feb;54(3):313-32. doi: 10.1016/s0301-0082(97)00061-0.
A discussion of the neuroanatomical systems thought to be of importance for the mediation of recognition memory in the rat warrants consideration of different, but not necessarily exclusive concepts. An important concept is the hypothesis that a dichotomy in the neural systems mediating spatial and non-spatial (item) memory exists in the rat. We have adopted a model of recognition memory suggesting that information about previously encountered items is stored in a dynamic pattern of neural activity and not in a localized representation. These patterns are features of distributed neuronal networks and different networks may process different forms of recognition memory. Two parallel-distributed neuronal networks are proposed in the rat. Network 1 is essential for the processing of non-spatial/item recognition memory processes and incorporates the cortical association areas such as TE1, TE2 and TE3, the rhinal cortices, the mediodorsal thalamic nucleus and prefrontal cortical areas. Network 2 comprises the hippocampus, mamillary bodies, anterior thalamic nuclei and medial prefrontal areas, especially the prelimbic cortex, and is suggested to be pivotal for the processing of spatial recognition memory.
关于被认为对大鼠识别记忆的介导至关重要的神经解剖系统的讨论，有必要考虑不同但不一定相互排斥的概念。一个重要的概念是这样一种假说，即在大鼠中存在介导空间记忆和非空间（项目）记忆的神经系统二分法。我们采用了一种识别记忆模型，该模型表明关于先前遇到的项目的信息存储在神经活动的动态模式中，而不是局部表征中。这些模式是分布式神经元网络的特征，不同的网络可能处理不同形式的识别记忆。在大鼠中提出了两个并行分布的神经元网络。网络1对于非空间/项目识别记忆过程的处理至关重要，它包含皮质联合区域，如TE1、TE2和TE3、鼻周皮质、丘脑背内侧核和前额叶皮质区域。网络2包括海马体、乳头体、丘脑前核和内侧前额叶区域，特别是边缘前皮质，被认为对空间识别记忆的处理至关重要。
