习得性安全和耐受性对大鼠酒精摄入量的影响。

Effects of learned safety and tolerance on alcohol consumption by the rat.

作者信息

Walton N Y, Roll P L, Thiel T R, Rogers J

出版信息

Psychopharmacology (Berl). 1978 May 31;57(3):263-6. doi: 10.1007/BF00426748.

Abstract

Evidence is presented that learned safety increases the rat's willingness to drink ethanol: induction of tolerance to ethanol following learned safety training produces a further increase. Rats with chronically implanted intragastric fistulae consumed substantially more (30%) alcohol when aversive post-ingestional effects were minimized by draining stomach contents during drinking than did rats allowed to retain stomach contents. Half the rats from each group were then made tolerant by prolonged forced alcohol intubation. Later testing showed an increase in alcohol consumption by rats receiving learned safety training or rendered tolerant, with the two factors being additive.

摘要

有证据表明，习得性安全会增加大鼠饮用乙醇的意愿：在习得性安全训练后对乙醇产生耐受性会进一步增强这种意愿。当通过在饮用期间排出胃内容物将摄入后厌恶效应降至最低时，长期植入胃内瘘管的大鼠摄入的酒精量比允许保留胃内容物的大鼠多得多（30%）。然后，通过延长强制酒精插管使每组一半的大鼠产生耐受性。后来的测试表明，接受习得性安全训练或产生耐受性的大鼠的酒精摄入量增加，这两个因素具有相加作用。