Gupta S, Gupta R K, Varma D R
Indian J Physiol Pharmacol. 1976 Jul-Sep;20(3):164-7.
The effect of streptolysin O (a streptococcal exotoxin) on the myocardial contractility of isolated and intact mammalian and amphibian heart has been investigated. Streptolysin O caused marked reduction or complete cessation of myocardial contractility of mammalian and amphibian heart both in vivo and in vitro. The effect of submaximal doses of streptolysin O on isolated atria was reversible after repeated washings and the myocardial depressant effect of streptolysin O on isolated atria was reversible after repeated washings and the myocardial depressant effect of streptolysin O was not antagonised by atropine. These observations would suggest that streptolysin O is cardiotoxic and may be involved in the causation of myocardial failure associated with acute rheumatic fever in man.
已对链球菌溶血素O（一种链球菌外毒素）对离体和完整的哺乳动物及两栖动物心脏心肌收缩力的影响进行了研究。链球菌溶血素O在体内和体外均导致哺乳动物和两栖动物心脏的心肌收缩力显著降低或完全停止。亚最大剂量的链球菌溶血素O对离体心房的作用在反复冲洗后是可逆的，且链球菌溶血素O对离体心房的心肌抑制作用在反复冲洗后是可逆的，并且链球菌溶血素O的心肌抑制作用不受阿托品拮抗。这些观察结果表明，链球菌溶血素O具有心脏毒性，可能与人急性风湿热相关的心肌衰竭的病因有关。
