[丙型病毒性肝炎慢性酒精中毒患者对α干扰素的治疗反应]
[Therapeutic response to alpha-interferon in chronic alcoholics with viral hepatitis C].
作者信息
Nikitin I G, Kuznetsov S L, Liuliaeva O D, Storozhakov G I, Kisliakov V A, Uskov Iu I
出版信息
Klin Med (Mosk). 1998;76(8):33-5.
PMID:9770965
Abstract
Hepatitis C was treated with interferon alpha in chronic alcoholics and control subjects without alcoholism. The results show that ethanol is an independent risk factor in natural progression of chronic hepatitis C. Moreover, it dose-dependently reduces probability of getting a reliable response to interferon therapy. This makes using interferon alpha treatment of hepatitis C in chronic alcoholics doubtful.
摘要
在慢性酒精性肝病患者和非酒精性对照受试者中，使用α干扰素治疗丙型肝炎。结果表明，乙醇是慢性丙型肝炎自然进展中的一个独立危险因素。此外，乙醇还会剂量依赖性地降低对干扰素治疗产生可靠反应的概率。这使得在慢性酒精性肝病患者中使用α干扰素治疗丙型肝炎变得可疑。
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