Nosova N A, Pavlov V A, Frash V N
Probl Tuberk. 1998(4):57-60.
Guinea pigs were injected with coal tar (CT) (intratracheally, 25 mg per animal once a week or a month for 2 or 8 months, respectively), then they were infected with MBT (H37Rv, 0.1 mg, subcutaneously). There were changes in hematological responses to MBT changes (in the context of the cell composition of bone marrow and peripheral blood), their pattern was associated with the mode of exposure to CT preceding MBT inoculation. The greatest differences were found in the responses of bone marrow lymphopoiesis and peripheral lymphocytes upon both exposures to CT. On greater exposure to CT (once a week) the changes in the blood system indicated that CT had an adverse effect on the course of experimental tuberculosis, while on lesser exposure (once a month), the effect of CT was more favourable.
将豚鼠气管内注射煤焦油（CT）（每只动物25毫克，分别每周或每月一次，持续2或8个月），然后皮下注射结核分枝杆菌（MBT，H37Rv，0.1毫克）。对MBT变化的血液学反应（在骨髓和外周血细胞组成的背景下）存在变化，其模式与接种MBT之前接触CT的方式有关。在两次接触CT时，骨髓淋巴细胞生成和外周淋巴细胞的反应差异最大。在更多接触CT（每周一次）时，血液系统的变化表明CT对实验性结核病的病程有不利影响，而在较少接触（每月一次）时，CT的影响更有利。
