[Changes in the ultrastructure of interneuronal connections in experimental chronic morphine poisoning].

To understand the mechanisms of brain activity and behaviour alterations in chronic morphine intoxication, it is especially important to analyze the changes occurring in the interneuronal connections. Analyzing cerebral cortical synapses during morphine treatment revealed that some new synapses formed. The newly formed synapses increased the total number of synapses of the cerebral cortex and reorganized synaptic architectonics. The changes in the synaptic architectonics accompanied ultrastructural changes of dendrites. The development of new synapses and changes of dendrites are the basis for the formation of pathological cerebral cortical systems.