Bogolepov N N
Vestn Ross Akad Med Nauk. 1998(8):16-9.
To understand the mechanisms of brain activity and behaviour alterations in chronic morphine intoxication, it is especially important to analyze the changes occurring in the interneuronal connections. Analyzing cerebral cortical synapses during morphine treatment revealed that some new synapses formed. The newly formed synapses increased the total number of synapses of the cerebral cortex and reorganized synaptic architectonics. The changes in the synaptic architectonics accompanied ultrastructural changes of dendrites. The development of new synapses and changes of dendrites are the basis for the formation of pathological cerebral cortical systems.
为了解慢性吗啡中毒时大脑活动和行为改变的机制，分析神经元间连接中发生的变化尤为重要。对吗啡治疗期间的大脑皮质突触进行分析发现，形成了一些新的突触。新形成的突触增加了大脑皮质突触的总数，并重组了突触结构。突触结构的变化伴随着树突的超微结构变化。新突触的形成和树突的变化是病理性大脑皮质系统形成的基础。
