Reunanen M I, Sotaniemi E A, Hakkarainen H K
Int J Clin Pharmacol Biopharm. 1976 Jul;14(1):15-9.
The timing of anticonvulsant-induced disturbances of calcium metabolism was investigated in ten epileptics before diphenylhydantoin therapy and during it for up to three years. There was a significant decrease in average serum calcium and an increase in average serum alkaline phosphatase one month after the commencement of the therapy, these values remaining constant thereafter. Decreased serum inorganic phosphate and elevated hydroxyproline levels were also seen in the patients during the followup. At any time after the start of the drug therapy, 10 to 40 per cent of the patients had abnormalities in one or more of these parameters. The findings suggest that prophylactic therapy with vitamin D is indicated from the earliest phase of anticonvulsant therapy to prevent the development of bone disease.
在10名癫痫患者中，研究了抗惊厥药物引起的钙代谢紊乱发生的时间，这些患者在苯妥英钠治疗前及治疗长达三年的过程中接受观察。治疗开始后1个月，血清钙平均值显著下降，血清碱性磷酸酶平均值升高，此后这些值保持稳定。随访期间患者还出现血清无机磷降低和羟脯氨酸水平升高的情况。在药物治疗开始后的任何时候，10%至40%的患者这些参数中的一项或多项出现异常。这些发现表明，从抗惊厥治疗的最早阶段就应进行维生素D预防性治疗，以预防骨病的发生。
