Claus J J, Kwa V I, Teunisse S, Walstra G J, van Gool W A, Koelman J H, Bour L J, Ongerboer de Visser B W
Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands.
Alzheimer Dis Assoc Disord. 1998 Sep;12(3):167-74. doi: 10.1097/00002093-199809000-00008.
The relation between quantitative spectral electroencephalogram (qEEG) parameters and subsequent rate of cognitive, functional, and behavioral decline in 82 consecutive patients with early probable Alzheimer disease (NINCDS-ADRDA criteria) was examined in a prospective study. The qEEG was performed at initial examination and global cognitive function, activities of daily living, and behavior were assessed at initial evaluation and after a period of 6 months. Using multiple linear regression analysis, higher frontocentral and parieto-occipital theta values, lower parieto-occipital beta values, and lower peak frequency were significantly associated with more decline in global cognitive function over the follow-up period. In addition, lower parieto-occipital beta values were significantly related to more decline in activities of daily living. These associations were independent of demographic (age, sex, and education) and disease characteristics [initial Cambridge Examination for Mental Disorders of the Elderly Cognitive test (CAMCOG) or Mini-Mental State Examination scores, estimated duration of symptoms, estimated prior rate of decline, and dementia severity]. In a separate multiple logistic regression analysis, prediction of rapidly progressive decline, defined as 8 or more points decline in CAMCOG scores (n = 21), could be made with parieto-occipital and frontocentral beta values. The results suggest that slowing on qEEG is a marker for subsequent rate of cognitive and functional decline in mildly demented AD patients, independent of demographic or disease characteristics.
在一项前瞻性研究中，对82例符合早期可能阿尔茨海默病（NINCDS-ADRDA标准）的连续患者，研究了定量脑电图（qEEG）参数与随后认知、功能和行为衰退率之间的关系。在初次检查时进行qEEG检查，并在初次评估时以及6个月后评估整体认知功能、日常生活活动和行为。使用多元线性回归分析，较高的额中央和顶枕部θ值、较低的顶枕部β值以及较低的峰值频率与随访期间整体认知功能的更多衰退显著相关。此外，较低的顶枕部β值与日常生活活动的更多衰退显著相关。这些关联独立于人口统计学因素（年龄、性别和教育程度）和疾病特征[初始老年精神障碍剑桥认知检查（CAMCOG）或简易精神状态检查得分、估计症状持续时间、估计先前衰退率和痴呆严重程度]。在一项单独的多元逻辑回归分析中，可根据顶枕部和额中央β值预测快速进行性衰退，定义为CAMCOG得分下降8分或更多（n = 21）。结果表明，qEEG减慢是轻度痴呆AD患者随后认知和功能衰退率的一个标志物，独立于人口统计学或疾病特征。
