Fukuda T, Mitani H, Tsutsumi M, Konishi Y, Hino O
Department of Experimental Pathology, Cancer Institute, Toshima-ku, Tokyo 170-8455, Japan.
Int J Oncol. 1998 Nov;13(5):957-61. doi: 10.3892/ijo.13.5.957.
Eker rats develop dominantly inherited renal carcinomas (RCs), with hereditary mutation, and following somatic mutation (Knudson's second hit) at tuberous sclerosis gene (Tsc2). We document the effect of transplacental administration of N-ethyl-N-nitrosourea to Eker (Eker/+) and non-Eker (+/+) rats (same genetic background). Although we observed no difference in the number of preneoplastic GST-P positive foci between Eker and non-Eker rats, interestingly we observed the specific development of hepatocellular adenomas only in Eker rats. The Tsc2 gene mutation might thus influence the phenotype of preneoplastic initiated hepatocytes.
埃克大鼠会发生显性遗传的肾癌（RCs），存在遗传性突变，随后在结节性硬化症基因（Tsc2）处发生体细胞突变（克努森的二次打击）。我们记录了经胎盘给予N-乙基-N-亚硝基脲对埃克（Eker/+）和非埃克（+/+）大鼠（相同遗传背景）的影响。虽然我们观察到埃克大鼠和非埃克大鼠之间的癌前谷胱甘肽S-转移酶P（GST-P）阳性病灶数量没有差异，但有趣的是，我们仅在埃克大鼠中观察到肝细胞腺瘤的特异性发展。因此，Tsc2基因突变可能会影响癌前起始肝细胞的表型。
