基质金属蛋白酶matrilysin（MMP - 7）参与人类胃癌和食管癌的进展。

Matrix metalloproteinase matrilysin (MMP-7) participates in the progression of human gastric and esophageal cancers.

作者信息

Adachi Y, Itoh F, Yamamoto H, Matsuno K, Arimura Y, Kusano M, Endoh T, Hinoda Y, Oohara M, Hosokawa M, Imai K

机构信息

First Department of Internal Medicine, Sapporo Medical University, Chuo-ku, Sapporo 060-8543, Japan.

出版信息

Int J Oncol. 1998 Nov;13(5):1031-5. doi: 10.3892/ijo.13.5.1031.

DOI:10.3892/ijo.13.5.1031

PMID:9772296

Abstract

Matrilysin is one of matrix metalloproteinases, which is supposed to have a specific role in tumor progression. Expression of matrilysin was investigated in gastric and esophageal cancers by an immunohistochemical examination. Matrilysin was expressed in all esophageal squamous cell carcinomas (13/13) and in the majority of gastric adenocarcinomas (31/35, 89%). The positive staining was observed in tumor cells of cancerous tissues. In gastric cancers, there were significant statistical correlations between matrilysin expression at the invasive front and nodal metastasis or advanced stage. These results suggest that overexpression of matrilysin has an important role in the progression of upper gastrointestinal cancers.

摘要

基质溶素是基质金属蛋白酶之一，被认为在肿瘤进展中具有特定作用。通过免疫组织化学检查研究了基质溶素在胃癌和食管癌中的表达情况。基质溶素在所有食管鳞状细胞癌（13/13）以及大多数胃腺癌（31/35，89%）中均有表达。在癌组织的肿瘤细胞中观察到阳性染色。在胃癌中，侵袭前沿的基质溶素表达与淋巴结转移或晚期之间存在显著的统计学相关性。这些结果表明基质溶素的过表达在上消化道癌的进展中起重要作用。