Berczi I, Chow D A, Baral E, Nagy E
Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, R3E 0W3, Canada.
Int J Oncol. 1998 Nov;13(5):1049-60. doi: 10.3892/ijo.13.5.1049.
It is certain that neuroimmune mechanisms play a role in host defence against cancer. However, this interaction is highly complex and many variations are possible according to the nature of the neoplasms involved. There are indications that adaptive immunity is present in a significant proportion of tumor bearing hosts, and this defence may be boosted by specially designed vaccines and cytokines. Natural immune mediators are also implicated in resistance against tumor development. Here we review the evidence suggesting that hormonal manipulation of the host can result in the elevation of immune defences against cancer. Such manipulation strengthens both the adaptive and natural immune defences of the host, both of which play significant roles. Natural defence mechanisms are boosted by cytokines and hormones during febrile reactions which are now known as the acute phase response. It is suggested that hormonal stimulation of immune mechanisms coupled with the usual immunostimulants already in use may be employed to good advantage for the combination immunotherapy of cancer. Modern molecular biology approaches permit the development of laboratory monitoring procedures which may be used for the prediction and follow-up of therapeutic success.
神经免疫机制在宿主对抗癌症的防御中发挥作用这一点是确定无疑的。然而，这种相互作用极为复杂，根据所涉及肿瘤的性质，可能存在多种变化。有迹象表明，相当一部分肿瘤宿主存在适应性免疫，而且这种防御可通过专门设计的疫苗和细胞因子得到增强。天然免疫介质也与抵抗肿瘤发展有关。在此，我们综述相关证据，这些证据表明对宿主进行激素调控可提高针对癌症的免疫防御。这种调控可增强宿主的适应性免疫和天然免疫防御，二者均发挥重要作用。在现在被称为急性期反应的发热反应过程中，细胞因子和激素可增强天然防御机制。有人提出，激素对免疫机制的刺激与现有的常用免疫刺激剂相结合，可能会在癌症联合免疫治疗中发挥良好作用。现代分子生物学方法使实验室监测程序得以发展，这些程序可用于预测治疗效果并进行随访。
