Yao M, Zhou X, Zha X
Liver Cancer Institute, Zhong Shan Hospital, Shanghai Medical University.
Zhonghua Yi Xue Za Zhi. 1997 May;77(5):382-4.
To elucidate the roles of integrins in tumorigenesis, progression, differentiation, invasiveness and metastasis, and the role of the integrin alpha 5 subunit in hepatocellular carcinoma (HCC).
79 formalin-fixed sections of hepatocellular carcinoma (HCC) were obtained. The integrin alpha 5 subunit was measured by immunohistochemistry assay (ABC method).
In 79 cases of HCC, cancerous tissues had lower expression than their adjacent non-tumor tissues (32.9% vs 81.0%, P < 0.01). The alpha 5 positive rate in small HCC (= < 5 cm in diameter) was higher than large HCC > 10 cm in diameter), being 55.6% and 10.0% respectively. Well-differentiated HCC expressed higher alpha 5 than poorly differentiated ones. The alpha 5 positive rates were lower in highly invasive HCC than those to low invasive ones.
Our study indicated that expression of the integrin alpha 5 subunit is correlated with growth, differentiation, invasiveness and metastasis of HCC. It is possible that alpha 5 subunit is a negative regulator to these biological parameters of HCC.
阐明整合素在肿瘤发生、发展、分化、侵袭和转移中的作用，以及整合素α5亚基在肝细胞癌（HCC）中的作用。
获取79例肝细胞癌的福尔马林固定切片。采用免疫组织化学分析（ABC法）检测整合素α5亚基。
在79例HCC中，癌组织的表达低于其相邻的非肿瘤组织（32.9%对81.0%，P<0.01）。小肝癌（直径≤5cm）的α5阳性率高于大肝癌（直径>10cm），分别为55.6%和10.0%。高分化HCC比低分化HCC表达更高的α5。高侵袭性HCC的α5阳性率低于低侵袭性HCC。
我们的研究表明，整合素α5亚基的表达与HCC的生长、分化、侵袭和转移相关。α5亚基有可能是HCC这些生物学参数的负调节因子。
