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地西泮的抗惩罚作用:与猪的电击和食物剥夺水平的相互作用

Antipunishment effects of diazepam: interaction with shock and food deprivation levels in pigs.

作者信息

Dantzer R

出版信息

Psychopharmacology (Berl). 1978 Jun 15;58(1):99-104. doi: 10.1007/BF00426797.

Abstract

The effects of 1mg/kg diazepam on punished behaviour of pigs were investigated under various degrees, of food deprivation and/or shock level. Responses emitted during the punishment signal were affected more by the shock level than by the degree of food deprivation while nonpunished response rates were modified by neither factor. Diazepam treatment increased the number of responses emitted during the punishment signal but interacted with the shock intensity: drug effects were attenuated when the shock intensity was severe, in spite of an equivalent control baseline. Diazepam also increased the overall rate of nonpunished responding. The drug treatment had no reliable effect on flinch and escape thresholds measured in separate experiments. The effects of diazepam on punished responding do not appear to be related to eventual changes in food motivation or sensitivity to electric shock.

摘要

研究了1毫克/千克地西泮在不同程度的食物剥夺和/或电击水平下对猪受罚行为的影响。惩罚信号期间发出的反应受电击水平的影响大于食物剥夺程度的影响,而非惩罚反应率则不受这两个因素的影响。地西泮治疗增加了惩罚信号期间发出的反应数量,但与电击强度相互作用:尽管有相当的对照基线,但当电击强度严重时,药物效果会减弱。地西泮还增加了非惩罚反应的总体速率。药物治疗对在单独实验中测量的退缩和逃避阈值没有可靠的影响。地西泮对受罚反应的影响似乎与食物动机或对电击的敏感性的最终变化无关。

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