Thune P
Romeriksklinikken, Strømmen.
Tidsskr Nor Laegeforen. 1998 Sep 10;118(21):3295-6.
A 14 year-old girl experienced a combined delayed and immediate type of allergy to chlorhexidine. She first developed an eczematous reaction in the face following the long-term application of an antiacne preparation. Use test (repeated Open Application Test, ROAT) on the forearm was positive. Epicutaneous tests with 1% chlorhexidine gluconate and acetate were both positive. About six months later she developed an urticarial rash and syncope after cleansing the skin with chlorhexidine gluconate. Prick tests were positive to 0.05% chlorhexidine gluconate and to 0.01% of the acetate solution. A 30 year-old man developed anaphylactic symptoms following treatment with an antiseptic dental gel containing 1% chlorhexidine gluconate. Prick test was positive to the gel and to chlorhexidine gluconate 0.5%.
一名14岁女孩对洗必泰出现了迟发型和速发型混合过敏反应。她在长期使用一种抗痤疮制剂后，面部首先出现了湿疹样反应。在前臂进行的使用测试（重复开放应用测试，ROAT）呈阳性。用1%葡萄糖酸氯己定和醋酸氯己定进行的皮肤试验均为阳性。大约六个月后，她在用葡萄糖酸氯己定清洁皮肤后出现了荨麻疹皮疹和晕厥。点刺试验对0.05%葡萄糖酸氯己定和0.01%醋酸溶液呈阳性。一名30岁男子在使用含1%葡萄糖酸氯己定的抗菌牙科凝胶治疗后出现过敏症状。点刺试验对该凝胶和0.5%葡萄糖酸氯己定呈阳性。
