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[高血压中的左心室肥厚与心血管风险]

[Left ventricular hypertrophy and cardiovascular risk in hypertension].

作者信息

Amabile G

机构信息

Service de Cardiologie A, Pr M. Bory, CHU Timone, Marseille.

出版信息

Ann Cardiol Angeiol (Paris). 1998 Feb;47(2):86-90.

PMID:9772934
Abstract

Left ventricular hypertrophy (LVH) of hypertension is characterized by an increased ventricular mass due to myocardial cell hypertrophy and development of collagen and capillaries. Detected in man by electrocardiography and echocardiography, it is difficult to study due to the lack of sensitivity of EEG and the poor reproductibility of echocardiography, and by the lack of systematization of the analysis criteria adopted by investigators. Despite these uncertainties, the pejorative prognostic value of LVH has been clearly established and, based on its relationship with other risk factors, it can be considered to be an integrator of cardiovascular risk, justifying the use of this marker rather than other more variable indicators such as BP. The improved prognosis related to regression of LVH in response to treatment is currently controversial. Preliminary results indicate a reduction of morbidity-mortality in hypertensive patients when LVH is decreased; these findings must be confirmed before reduction of LVH can constitute an objective and antihypertensive treatment.

摘要

高血压左心室肥厚(LVH)的特征是由于心肌细胞肥大以及胶原蛋白和毛细血管的发育导致心室质量增加。通过心电图和超声心动图在人体中检测到LVH,但由于脑电图缺乏敏感性、超声心动图再现性差以及研究者采用的分析标准缺乏系统性,因此难以对其进行研究。尽管存在这些不确定性,但LVH的不良预后价值已得到明确证实,并且基于其与其他危险因素的关系,可将其视为心血管风险的综合指标,这证明使用该标志物而非其他更易变的指标(如血压)是合理的。目前,与LVH对治疗反应的消退相关的预后改善存在争议。初步结果表明,当LVH减轻时,高血压患者的发病率和死亡率会降低;在LVH的减轻能够构成客观的降压治疗之前,这些发现必须得到证实。

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