Zenker M, Klinge J, Krüger C, Singer H, Scharf J
University Hospital for Children and Adolescents, Erlangen, Germany.
J Perinat Med. 1998;26(3):231-4.
The administration of non-steroidal antiinflammatory drugs (NSAID) has occasionally been related to fetal and neonatal cardiopulmonary, gastrointestinal, cerebral and renal complications. This report describes a term newborn with severe persistent pulmonary hypertension due to premature closure of the ductus arteriosus following a 5 day maternal treatment with diclofenac two weeks before delivery. Pulmonary hypertension only responded to unusually high doses of inhaled NO. The treatment was necessary for 22 days suggesting structural alteration of pulmonary vasculature. The child recovered, but tricuspid regurgitation persisted, presumably because of irreversible ischemic damage of one papillary muscle. This is the first reported case of persistent pulmonary hypertension of the newborn (PPHN) in association with maternal diclofenac treatment and represents a most severe form of PPHN induced by NSAID.
非甾体抗炎药（NSAID）的使用偶尔会与胎儿及新生儿的心肺、胃肠道、脑部和肾脏并发症相关。本报告描述了一名足月儿，其在母亲分娩前两周接受了为期5天的双氯芬酸治疗后，因动脉导管过早关闭而出现严重持续性肺动脉高压。肺动脉高压仅对异常高剂量的吸入一氧化氮有反应。治疗持续了22天，提示肺血管结构改变。患儿康复，但三尖瓣反流持续存在，推测是由于一个乳头肌发生了不可逆的缺血性损伤。这是首例报道的与母亲使用双氯芬酸治疗相关的新生儿持续性肺动脉高压（PPHN）病例，代表了由NSAID诱发的最严重形式的PPHN。
